Metformin is a widely accepted, effective, well-tolerated, and cost-effective drug for the treatment of T2D. Pharmacological treatment of T2D can be added to lifestyle modifications and involves treating insulin resistance, typically with metformin. Living a healthy lifestyle by increasing physical activity and considering weight management can help in mitigating the incidence and severity of complications. Ideal treatments must restore proper functionality and sensitization of pancreatic β cells, while also creating a surmountable response to the underlying autoimmune dysfunction. The treatment for a multifaceted disease such as diabetes must be considered in the context of prevention. 1 The need for adequate and cost-effective treatment is becoming increasingly important. T1D accounts for 5.2% of all diabetes cases, with T2D making up the rest. 2 Type 1 diabetes (T1D) is an autoimmune disease characterized by accrued damage to pancreatic islet β cells, while type 2 diabetes (T2D) is characterized primarily by insulin resistance. 1 Apart from the direct effects to human health, the most common serious complications of diabetes include blindness, heart disease, lowerlimb amputation, and kidney failure. 1 According to the Centers for Disease Control and Prevention’s National Diabetes Statistics Report for 2020, 10.5% of the US population has been diagnosed with diabetes. On evaluation, current primary literature sources suggest that umbilical cord MSCs appear to have the most potential, with particular future implications for exosome research.ĭiabetes Mellitus (DM) is a disease with an increasing incidence rate that affects all age groups. This review highlights 3 lineages of MSCs-bone marrow MSCs, adipose-derived (ADSCs), and umbilical cord (UBC-MSCs) - and summarizes the current feasibility and efficacy of each. There are several subtypes of MSCs, and each subtype is accompanied by a unique array of pros and cons. Mesenchymal stem cells (MSCs) are well known for their tissue regenerative action and have shown promising results for restoring β islet cell function as well as ameliorating sequelae of DM. The dysfunction of β islet cells is a primary complication that requires treatment and may lead to several life-threatening complications including blindness, heart disease, and kidney failure. Both type 1 (T1D) and type 2 (T2D) diabetes are classifications that require lifetime management. Diabetes Mellitus (DM) is a disease with increasing incidence rates and global awareness.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |